|
KMID : 0370220230670030182
|
|
Yakhak Hoeji
2023 Volume.67 No. 3 p.182 ~ p.188
|
|
|
The Effect of Umbraulva japonica on the Stimulation of Anagen Phase
|
|
Kang Jung-Il
Kim You-Ri
Kim Hae-Ri
Yoo Eun-Sook
Kang Hee-Kyoung
|
|
|
Abstract
|
|
|
This study was conducted to evaluate the effects of Umbraulva japonica extract on the hair growth. Treatmentwith U. Japonica extract significantly increased the proliferation of dermal papilla cells (DPCs), a central regulator of thehair cycle. When isolated rat vibrissa follicles were treated with U. Japonica extract for 21 d, the hair-fiber lengths of thevibrissa follicles increased. When examined the activity of 5α-reductase, which converts testosterone to dihydrotestosterone(DHT), a main cause of androgenetic alopecia, U. Japonica extract did not inhibit the 5α-reductase activity. Moreover, wefound that the U. Japonica extract also significantly accelerated anagen phase in vivo. These results suggest that the U.
Japonica extract has the potential to treat alopecia via the stimulation of anagen phase.
|
|
|
KEYWORD
|
|
|
Umbraulva japonica, Hair growth, Anagen, Dermal papilla cells, Hair-fiber lengths
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|